Author/Authors :
Mirjana Popsavin، نويسنده , , Ljilja Torovi ، نويسنده , , Vesna Koji ، نويسنده , , Gordana Bogdanovi ، نويسنده , , Sa a Spai ، نويسنده , , Velimir Popsavin، نويسنده ,
Abstract :
A divergent synthesis of two novel tiazofurin analogues, 2-(3-deoxy-3-fluoro-β- -xylofuranosyl)thiazole-4-carboxamide (2) and 2-(3-acetamido-3-deoxy-β- -xylofuranosyl)thiazole-4-carboxamide (3), has been achieved starting from -glucose. Both nucleoside analogues were evaluated for their in vitro cytotoxicity against several human leukaemia and solid tumour cell lines.
