Title of article
Design and synthesis of dimeric HIV-1 integrase inhibitory peptides
Author/Authors
Krzysztof Krajewski، نويسنده , , Ya-Qiu Long، نويسنده , , Christophe Marchand، نويسنده , , Yves Pommier، نويسنده , , Peter P. Roller، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
3
From page
3203
To page
3205
Abstract
Dimers of known HIV-1 integrase inhibitory hexapeptide H-His-Cys-Lys-Phe-Trp-Trp-NH2 containing different lengths of cross linkers in the place of cysteine residue, were designed, and synthesized. The inhibitory potency of these dimeric peptides is consistently higher than the lead hexapeptide. The dimeric peptide with djenkolic acid linker exhibited IC50 values of 5.3 and 6.5 μM, for 3′-end processing and strand transfer, respectively.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793537
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