Title of article
Design and parallel synthesis of piperidine libraries targeting the nociceptin (N/OFQ) receptor
Author/Authors
Zhengming Chen، نويسنده , , Wendy S. Miller، نويسنده , , Yan-Shen Shan، نويسنده , , Kenneth J. Valenzano، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
6
From page
3247
To page
3252
Abstract
Based on literature structures, we proposed a pharmacophore for NOP receptor ligands and used it as a guide for the design of a focused piperidine library and an optimization library. Potent NOP receptor agonists and antagonists were obtained from these libraries as well as a few potent, mu selective agonists.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793546
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