Title of article
Glycidol-carbohydrate hybrids: a new family of DNA alkylating agents
Author/Authors
Kazunobu Toshima، نويسنده , , Yukiko Okuno، نويسنده , , Shuichi Matsumura، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
3
From page
3281
To page
3283
Abstract
Novel and chiral glycidol–carbohydrate hybrids possessing an epoxy group as a DNA alkylating moiety were designed and synthesized. These artificial hybrids selectively alkylated DNA at the N-7 sites of the guanines and cleaved DNA without any additives. The binding ability of the glycidol was significantly enhanced by the attachment of the carbohydrate.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793553
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