Title of article
Muraymycins, novel peptidoglycan biosynthesis inhibitors: synthesis and SAR of their analogues
Author/Authors
Ayako Yamashita، نويسنده , , Emily Norton، نويسنده , , Peter J. Petersen، نويسنده , , Beth A. Rasmussen، نويسنده , , Guy Singh، نويسنده , , Youjin Yang، نويسنده , , Tarek S. Mansour، نويسنده , , Douglas M. Ho، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
6
From page
3345
To page
3350
Abstract
A series of Muraymycin analogues was synthesized. These analogues showed excellent antimicrobial activity against gram-positive organisms. These analogues also showed excellent inhibitory activity against the target peptidoglycan biosynthesis enzyme MraY, the cell membrane associated transglycosylase responsible for the formation of Lipid II.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793567
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