Title of article
Combinatorial modification of natural products: synthesis and in vitro analysis of derivatives of thiazole peptide antibiotic GE2270 A: A-ring modifications
Author/Authors
Jeffrey Clough، نويسنده , , Shaoqing Chen، نويسنده , , Eric M. Gordon، نويسنده , , Corinne Hackbarth، نويسنده , , Stuart Lam، نويسنده , , Joaquim Trias، نويسنده , , Richard J. White، نويسنده , , Gianpaolo Candiani، نويسنده , , Stefano Donadio، نويسنده , , Gabriella Roman?، نويسنده , , Romeo Ciabatti، نويسنده , , Jeffrey W. Jacobs، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
6
From page
3409
To page
3414
Abstract
Thiazole peptide GE2270 A (1) possesses potent antimicrobial activity against many gram-positive pathogens, including methicillin resistant Staphylococcus aureus (S. aureus, MRSA; MIC90=0.06 μg/mL) and vancomycin resistant Enterococcus spp. (VRE; MIC90=0.03 μg/mL); however its poor aqueous solubility has prohibited its development for the clinical treatment of infections. An integrated combinatorial and medicinal chemistry program was employed to identify derivatives of1 that retain activity but possess greatly enhanced aqueous solubility.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793578
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