Title of article :
Pyrimido[1,2-b]-1,2,4,5-tetrazin-6-ones as HCMV protease inhibitors: a new class of heterocycles with flavin-like redox properties
Author/Authors :
Martin J. Di Grandi، نويسنده , , Kevin J. Curran، نويسنده , , Ellen Z. Baum، نويسنده , , Geraldine Bebernitz، نويسنده , , George A. Ellestad، نويسنده , , Wei-Dong Ding، نويسنده , , Stanley A. Lang Jr.، نويسنده , , Miriam Rossi، نويسنده , , Jonathan D. Bloom، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2003
Pages :
4
From page :
3483
To page :
3486
Abstract :
The synthesis and biological activity of pyrimidotetrazin-6-ones against HCMV protease is described. The mechanism of action for these inhibitors is the oxidation of several cysteine residues to generate cross-linked enzyme.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
2003
Journal title :
Bioorganic & Medicinal Chemistry Letters
Record number :
793593
Link To Document :
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