Author/Authors :
Shu-Hui Chen، نويسنده , , Jason Lamar، نويسنده , , Frantz Victor، نويسنده , , Nancy Snyder، نويسنده , , Robert Johnson، نويسنده , , Beverly A. Heinz، نويسنده , , Mark Wakulchik، نويسنده , , Q. May Wang، نويسنده ,
Abstract :
We describe herein the synthesis and biological evaluation of a series of tripeptidyl α-ketoamides as human rhinovirus (HRV) 3C protease inhibitors. The most potent inhibitor discussed in this manuscript, 4I, exhibited impressive enzyme inhibitory activity as well as antiviral activity against HRV-14.
