Author/Authors :
Ranjit C. Desai، نويسنده , , Dominick F. Gratale، نويسنده , , Wei Han، نويسنده , , Hiroo Koyama، نويسنده , , Edward Metzger، نويسنده , , Victoria K. Lombardo، نويسنده , , Karen L. MacNaul، نويسنده , , Thomas W. Doebber، نويسنده , , Joel P. Berger، نويسنده , , Kwan-Leung Chan MD FRCPC، نويسنده , , Ronald Franklin، نويسنده , , David E. Moller، نويسنده , , James V. Heck، نويسنده , , Soumya P. Sahoo، نويسنده ,
Abstract :
A series of novel aryloxazolidine-2,4-diones was synthesized. A structure–activity relationship study of these compounds led to the identification of potent, orally active PPAR dual α/γ agonists. Based on the results of efficacy studies in the db/db mice model of type 2 diabetes and the desired pharmacokinetic parameters, compound 12 was selected for further profiling.
