Title of article
Structure–Activity relationships within a series of caspase inhibitors: effect of leaving group modifications
Author/Authors
Brett R. Ullman، نويسنده , , Teresa Aja، نويسنده , , Thomas L. Deckwerth، نويسنده , , Jose Luis Diaz-Rossello، نويسنده , , Julia Herrmann، نويسنده , , Vincent J. Kalish، نويسنده , , Donald S. Karanewsky، نويسنده , , Steven P. Meduna، نويسنده , , Kip Nalley، نويسنده , , Edward D. Robinson، نويسنده , , Silvio P. Roggo، نويسنده , , Robert O. Sayers، نويسنده , , Stephan Albert Schmitz، نويسنده , , Robert J. Ternansky، نويسنده , , Kevin J. Tomaselli، نويسنده , , Joe C. Wu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
3623
To page
3626
Abstract
Various aryloxy methyl ketones of the 1-naphthyloxyacetyl-Val-Asp backbone have been prepared. A systematic study of their structure–activity relationship (SAR) related to caspases 1, 3, 6, and 8 is reported. Highly potent irreversible broad-spectrum caspase inhibitors have been identified. Their efficacy in cellular models of cell death and inflammation are also discussed.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793623
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