Author/Authors :
Jie-Fei Cheng، نويسنده , , Akira Ishikawa, Terry L. Wilson، نويسنده , , Yoshinori Ono، نويسنده , , Thomas Arrhenius، نويسنده , , Alex Nadzan، نويسنده ,
Abstract :
A novel series of chromene-based TNF-α inhibitors is described. These chromene derivatives inhibit bacterial lipopolysaccharide (LPS) stimulated production of TNF-α from human peripheral blood mononuclear cells (PBMC). Additionally, these compounds inhibit NF-kB mediated transcription activation.
