Title of article
Biological evaluation of sphingomyelin analogues as inhibitors of sphingomyelinase
Author/Authors
Minoru Taguchi، نويسنده , , Ken-ichi Goda، نويسنده , , Kikuo Sugimoto، نويسنده , , Tomoko Akama، نويسنده , , Kyoko Yamamoto، نويسنده , , Taizo Suzuki، نويسنده , , Yasumitsu Tomishima، نويسنده , , Mariko Nishiguchi، نويسنده , , Koshi Arai، نويسنده , , Kenzo Takahashi، نويسنده , , Takeo Kobori، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
3681
To page
3684
Abstract
Seeking neutral sphingomyelinase inhibitors, we designed and synthesized hydrolytically stable analogues of sphingomyelin. These novel analogues replace the phosphodiester moiety of sphingomyelin with carbamate and urea moiety, resulting in inhibition of neutral sphingomyelinase. Compound 1 prevented ceramide generation and apoptotic neuronal cell death in a model of ischemia based on organotypic hippocampal slice cultures.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793635
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