Title of article
Aryl piperazine melanocortin MC4 receptor agonists
Author/Authors
Brian Dyck، نويسنده , , Jessica Parker، نويسنده , , Teresa Phillips، نويسنده , , Lee Carter، نويسنده , , Brian Murphy، نويسنده , , Robin Summers، نويسنده , , Julia Hermann، نويسنده , , Tracy Baker، نويسنده , , Mary Cismowski، نويسنده , , John Saunders، نويسنده , , Val Goodfellow، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
3793
To page
3796
Abstract
Incorporation of substituted phenyl piperazine privileged structures into a known MC4 specific dipeptoid consensus sequence resulted in a series of potent (EC50=24 nM) and selective MC4-R agonists. We report the SAR of this series of compounds using in vitro cAMP functional assays in cells transfected with the MC4 or other melancortin receptors.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793659
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