Author/Authors :
Michel Gallant، نويسنده , , Michel Belley، نويسنده , , Marie-Claude Carrière، نويسنده , , Anne Chateauneuf، نويسنده , , Danielle Denis، نويسنده , , Nicolas Lachance، نويسنده , , Sonia Lamontagne، نويسنده , , Kathleen M. Metters، نويسنده , , Nicole Sawyer، نويسنده , , Deborah Slipetz، نويسنده , , Jean François Truchon، نويسنده , , Marc Labelle، نويسنده ,
Abstract :
Potent and selective ligands for the human EP3 prostanoid receptor are described. Triaryl compounds bearing an ortho-substituted propionic acid moiety were identified as potent EP3 antagonists based on the SAR described herein. The binding affinities of key compound on all eight human prostanoid receptors is reported.
