Author/Authors :
Nan-Horng Lin، نويسنده , , L.E. Wang، نويسنده , , Jerry Cohen، نويسنده , , Wen-Zhen Gu، نويسنده , , David Frost، نويسنده , , Haiying Zhang، نويسنده , , Saul Rosenberg، نويسنده , , Hing Sham، نويسنده ,
Abstract :
Farnesyltransferase inhibitors (FTIs) have emerged as a novel class of anticancer agents. Analogues of the potent FTI, 4-[3-biphenyl-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-1-yl-benzonitrile, were synthesized and tested in vitro for their inhibitory activities. The most promising compound identified from this series is analogue 11 that possesses potent enzymatic and cellular activities.
