Author/Authors :
Min Chu، نويسنده , , Ronald Mierzwa، نويسنده , , Ling Xu، نويسنده , , Shu-Wei Yang، نويسنده , , Ling He، نويسنده , , Mahesh Patel، نويسنده , , Jill Stafford، نويسنده , , David Macinga، نويسنده , , Todd Black، نويسنده , , Tze-Ming Chan، نويسنده , , Vincent Gullo، نويسنده ,
Abstract :
A novel acyl carrier protein synthase inhibitor, Sch 538415 (1), was isolated from an unidentified bacterial microbe. Structure elucidation of 1 was accomplished based on analysis of spectroscopic data including UV, MS and 2D-NMR spectra. Compound 1 exhibited inhibitory activity in the acyl carrier protein synthase (AcpS) assay with an IC50 value of 4.19 μM and showed antibacterial activity against Staphylococcus aureus in the agar diffusion assay.
