Title of article
Synthesis of linked carbohydrates and evaluation of Their binding for 16S RNA by mass spectrometry
Author/Authors
Baogen Wu، نويسنده , , Jun Yang، نويسنده , , Dale Robinson، نويسنده , , Steve Hofstadler، نويسنده , , Rich Griffey، نويسنده , , Eric E. Swayze، نويسنده , , Yun He، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
3915
To page
3918
Abstract
A library of linked molecules were synthesized from the common sugar moieties existing in the natural amino glycosides. These linked molecules were screened against bacterial 16S RNA for their binding affinity using a mass spectrometry-based technology. Some of these compounds exhibited low micromolar affinity and could serve as leads for further development as antibacterial agents.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793685
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