Title of article
Novel radiosynthesis of PET HSV-tk gene reporter probes [18F]FHPG and [18F]FHBG employing dual Sep-Pak SPE techniques
Author/Authors
Ji-Quan Wang، نويسنده , , Qi-Huang Zheng، نويسنده , , Xiangshu Fei، نويسنده , , Bruce H. Mock، نويسنده , , Gary D. Hutchins، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
6
From page
3933
To page
3938
Abstract
Positron emission tomography (PET) herpes simplex virus thymidine kinase (HSV-tk) gene reporter probes 9-[(3-[18F]fluoro-1-hydroxy-2-propoxy)methyl]guanine ([18F]FHPG) and 9-(4-[18F]fluoro-3-hydroxymethylbutyl)guanine ([18F]FHBG) were prepared by nucleophilic substitution of the appropriate tosylated precursors with [18F]KF/Kryptofix 2.2.2 followed by a quick deprotection reaction and purification with a simplified dual Silica Sep-Pak solid-phase extraction (SPE) method in 15–30% radiochemical yield.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793689
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