Title of article
Design and synthesis of orally active inhibitors of TNF synthesis as anti-rheumatoid arthritis drugs
Author/Authors
Jian Jeffrey Chen، نويسنده , , Nolan Dewdney، نويسنده , , Xiaohong Lin، نويسنده , , Robert L. Martin، نويسنده , , Keith A. M. Walker، نويسنده , , Jane Huang، نويسنده , , Frances Chu، نويسنده , , Elsie Eugui، نويسنده , , Anna Mirkovich، نويسنده , , Yong Kim، نويسنده , , Keshab Sarma، نويسنده , , Humberto Arzeno، نويسنده , , Harold E. Van Wart، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
3951
To page
3954
Abstract
A novel series of TNF inhibitors was identified based on the screening of existing MMP inhibitor libraries. Further SAR optimization led to the discovery of a novel lead compound. Its synthesis, efficacy in experimental animal models, and pharmacokinetic data are discussed.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793693
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