Title of article
New anti-malarial peroxides with In vivo potency derived from spongean metabolites
Author/Authors
Nobutoshi Murakami، نويسنده , , Motoyuki Kawanishi، نويسنده , , Huq Mohammad Mostaqul، نويسنده , , Jie Li، نويسنده , , Sawako Itagaki، نويسنده , , Toshihiro Horii، نويسنده , , Motomasa Kobayashi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
4081
To page
4084
Abstract
The structure–activity relationship of the anti-malarial substance 3 having a 6-carbomethoxymethyl-3-methoxy-1,2-dioxane structure was studied. The ester portion of the peroxide 3, showing little in vivo efficacy in malaria-infected mice in spite of the potent in vitro activity, was hydrolyzed in serum to afford an inactive free acid 4. The amide analogues (8 and 9) robust to mouse serum were disclosed to exhibit in vivo anti-malarial potency.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793723
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