Author/Authors :
José R. Tormo، نويسنده , , Teresa Gallardo، نويسنده , , Eva Peris، نويسنده , , Almudena Bermejo، نويسنده , , Nuria Cabedo، نويسنده , , Ernesto Estornell، نويسنده , , M. Carmen Zafra-polo، نويسنده , , Diego Cortes، نويسنده ,
Abstract :
Modifications in the terminal α,β-unsaturated γ-methyl-γ-lactone moiety or in the alkyl chain that links this terminal γ-lactone with the α,α′-dihydroxylated THF system of the natural mono-tetrahydrofuranic acetogenins, annonacin and annonacinone, led to the preparation of eight semisynthetic derivatives. Their inhibitory effects on mitochondrial complex I is discussed and compared with that of the classical complex I inhibitor, rotenone.
