Title of article
High affinity, bioavailable 3-Amino-1,4-benzodiazepine-Based γ-Secretase inhibitors
Author/Authors
Andrew P. Owens، نويسنده , , Alan Nadin، نويسنده , , Adam C. Talbot، نويسنده , , Earl E. Clarke، نويسنده , , Timothy Harrison، نويسنده , , Huw D. Lewis، نويسنده , , Michael Reilly، نويسنده , , Jonathan D. J. Wrigley، نويسنده , , José L. Castro، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
3
From page
4143
To page
4145
Abstract
In this paper, we describe the development of a novel series of high affinity, orally bioavailable 3-amino-1,4 benzodiazepine-based γ-secretase inhibitors for the potential treatment of Alzheimerʹs disease. We disclose structure–activity relationships based around the 1, 3 and 5 positions of the benzodiazepine core structure.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793736
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