Author/Authors :
N. Selvakumar، نويسنده , , Mohammed A. Raheem، نويسنده , , Manoj Kumar Khera، نويسنده , , Trideep V. Rajale، نويسنده , , Magadi Sitaram Kumar، نويسنده , , Sreenivas Kandepu، نويسنده , , Jagattaran Das، نويسنده , , R. Rajagopalan، نويسنده , , Javed Iqbal، نويسنده , , Sanjay Trehan، نويسنده ,
Abstract :
The influence of an ethylene-oxy spacer element between the heterocycle and the aromatic ring in linezolid is reported. The introduction of such spacer group generated compounds with inferior antibacterial activity. However, the conversion of the acetamide group present in the linezolid analogues to either thiocarbamate or thioacetamide functionality restored the activity. The synthesis of linezolid analogues possessing the ethylene-oxy spacer group along with SAR studies with different heterocycles and preparation of some thiocarbonyl compounds possessing potent antibacterial property are presented.
