Title of article :
A simple stereoselective synthesis and biological evaluation of FR181157: orally active prostacyclin mimetic
Author/Authors :
Kouji Hattori، نويسنده , , Seiichiro Tabuchi، نويسنده , , Osamu Okitsu، نويسنده , , Kiyoshi Taniguchi، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2003
Abstract :
Synthetic method of novel prostaglandin (PG) mimetic: FR181175 without PG skeleton are described. The key to success is creation of a chiral epoxide using Sharpless AD reaction with high ee yield. FR181157 shows high potency and agonist efficacy at the IP receptor and has good bioavailability.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
