Title of article
Heterocyclic aminopyrrolidine derivatives as melatoninergic agents
Author/Authors
Li-Qiang Sun، نويسنده , , Jie Chen، نويسنده , , Ronald J. Mattson، نويسنده , , James R. Epperson، نويسنده , , Jeffrey A. Deskus، نويسنده , , Wen-Sen Li، نويسنده , , Katherine Takaki، نويسنده , , Donald B. Hodges، نويسنده , , Lawrence Iben، نويسنده , , Cathy D. Mahle، نويسنده , , Astrid Ortiz، نويسنده , , David Molstad، نويسنده , , Elaine Ryan، نويسنده , , Krishnaswamy Yeleswaram، نويسنده , , Cen Xu، نويسنده , , Guanglin Luo، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
4381
To page
4384
Abstract
A series of chiral heterocyclic aminopyrrolidine derivatives was synthesized as novel melatoninergic ligands. Binding affinity assays were performed on cloned human MT1 and MT2 receptors, stably expressed in NIH3T3 cells. Compound 16 was identified as an orally bioavailable agonist at MT1 and MT2 melatonin receptors with low vasoconstrictive activity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793785
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