Title of article
Stable analogues of geranylgeranyl diphosphate possessing improved geranylgeranyl versus farnesyl protein transferase inhibitory selectivity
Author/Authors
Filippo Minutolo، نويسنده , , Simone Bertini، نويسنده , , Laura Betti، نويسنده , , Romano Danesi، نويسنده , , Gianbattista Gervasi، نويسنده , , Gino Giannaccini، نويسنده , , Chiara Papi، نويسنده , , Giorgio Placanica، نويسنده , , Silvia Barontini، نويسنده , , Simona Rapposelli، نويسنده , , Marco Macchia، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
4405
To page
4408
Abstract
Phosphonoacetamido(oxy) groups have proven to be good mimics of the diphosphate portion in geranylgeranyl protein transferase I (GGTase I) inhibitors. The introduction of small alkyl groups (Me, Et) into the diphosphate mimic moiety caused a further decrease in collateral farnesyl protein transferase (FTase) inhibitory activity, thereby improving GGTase I over FTase selectivity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793790
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