Title of article
Novel mechanism of inhibiting β-Lactamases by sulfonylation using β-Sultams
Author/Authors
Michael I. Page، نويسنده , , Paul S. Hinchliffe، نويسنده , , J. Matthew Wood، نويسنده , , Lindsay P. Harding، نويسنده , , Andrew P. Laws، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
4489
To page
4492
Abstract
β-Sultams are the sulfonyl analogues of β-lactams and N-acyl β-sultams are novel inactivators of the class C β-lactamase of Enterobacter cloacae P99. The rates of inactivation show a similar pH-rate dependence as that exhibited by the β-lactam antibiotics and with ESIMS data it is suggested that β-sultams sulfonylate the active site serine residue to form a sulfonate ester.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793808
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