Title of article :
New orally active PDE4 inhibitors with therapeutic potential
Author/Authors :
Hiroshi Ochiai، نويسنده , , Akiharu Ishida، نويسنده , , Tazumi Ohtani، نويسنده , , Kensuke Kusumi، نويسنده , , Katuya Kishikawa، نويسنده , , Takaaki Obata، نويسنده , , Hisao Nakai، نويسنده , , Masaaki Toda، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
Structural optimization of pyrazolopyridine derivative 2, which is one of the newly discovered chemical leads for PDE4 inhibitors from our in-house library, was carried out successfully. The process of discovery of new orally active PDE4 inhibitors, which are expected to possess therapeutic potential, is presented and their structure–activity relationships are discussed.
Keywords :
PDE4 , Pyrazolopyrioline , inhibitor , Orally active.* Corresponding author. Tel.:+81-75-961-1151 , fax:+81-75-962-9314 , e-mail: hi.nakai@ono.co.jp
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
