Discovery of a novel series of DHODH inhibitors by a docking procedure and QSAR refinement
Author/Authors :
Johann Leban، نويسنده , , Wael Saeb، نويسنده , , Gabriel Garcia، نويسنده , , Roland Baumgartner، نويسنده , , Bernd Kramer، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Pages :
4
From page :
55
To page :
58
Abstract :
A novel series of DHODH inhibitors was developed based on a lead which was obtained by a docking procedure and a medicinal chemistry exploration. The activity of the initial lead was improved by a QSAR method to yield low nanomolar inhibitors.
