Author/Authors :
Yue Mei Zhang، نويسنده , , Stuart Cockerill، نويسنده , , Stephen B. Guntrip، نويسنده , , David Rusnak، نويسنده , , Kathryn Smith، نويسنده , , Dana Vanderwall، نويسنده , , Edgar Wood، نويسنده , , Karen Lackey، نويسنده ,
Abstract :
A series of 6-alkoxy-4-anilinoquinazoline compounds was prepared and evaluated for in vitro inhibition of the erbB2 and EGFR kinase activity. The IC50 values of the best compounds were below 0.10 uM. Further, several of these compounds inhibit the growth of erbB2 and EGFR over-expressing tumor cell lines at concentrations below 1 uM.
