Title of article
Synthesis of antitumor 6-alkylidenepenicillanate sulfones and related 3-alkylidene-2-azetidinones
Author/Authors
Grigory Veinberg، نويسنده , , Irina Shestakova، نويسنده , , Maxim Vorona، نويسنده , , Iveta Kanepe، نويسنده , , Edmunds Lukevics، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
147
To page
150
Abstract
6-Alkylidenepenicillanate sulfoxides and sulfones were synthesized on the base of 6-oxopenicillanate esters. The targeted splitting of their thiazolidine ring led to the formation of 3-alkylidene substituted 4-heteryldithio and 4-methylsulfonyl azetidin-2-ones. Some of mono and bicyclic β-lactams revealed potent cytotoxic properties towards monolayer tumor cells in <10-μM concentrations.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793944
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