Author/Authors :
Hiroshi Ochiai، نويسنده , , Tazumi Ohtani، نويسنده , , Akiharu Ishida، نويسنده , , Kensuke Kusumi، نويسنده , , Masashi Kato، نويسنده , , Hiroshi Kohno، نويسنده , , Katuya Kishikawa، نويسنده , , Takaaki Obata، نويسنده , , Hisao Nakai، نويسنده , , Masaaki Toda، نويسنده ,
Abstract :
Based on the hypothesis that the dose-limiting side effects of PDE4 inhibitors could be mediated via the central nervous system (CNS), design and synthesis of a hydrophilic analogue is considered to be one approach to improving the side-effect profile of Ariflo™ 1. Water-soluble piperidine derivatives were found to possess therapeutic potential.
