Title of article :
Exploration of the P1 SAR of aldehyde cathepsin K inhibitors
Author/Authors :
John G. Catalano، نويسنده , , David N. Deaton، نويسنده , , Eric S. Furfine، نويسنده , , Annie M. Hassell، نويسنده , , Robert B. McFadyen، نويسنده , , Aaron B. Miller، نويسنده , , Larry R. Miller، نويسنده , , Lisa M. Shewchuk، نويسنده , , Derril H. Willard Jr.، نويسنده , , Lois L. Wright، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Pages :
4
From page :
275
To page :
278
Abstract :
The synthesis and biological activity of a series of aldehyde inhibitors of cathepsin K are reported. Exploration of the properties of the S1 subsite with a series of α-amino aldehyde derivatives substituted at the P1 position afforded compounds with cathepsin K IC50s between 52 μM and 15 nM.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
2004
Journal title :
Bioorganic & Medicinal Chemistry Letters
Record number :
793969
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=793969
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