Title of article
4,5-Disubstituted-1,3-oxazolidin-2-imine derivatives: a new class of orally bioavailable nitric oxide synthase inhibitor
Author/Authors
Shigeo Ueda، نويسنده , , Hideo Terauchi، نويسنده , , Akihiro Yano، نويسنده , , Motoharu Ido، نويسنده , , Masashi Matsumoto، نويسنده , , Motoji Kawasaki، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
313
To page
316
Abstract
In our search for a novel class of inducible nitric oxide synthase (iNOS) inhibitors, 1,3-oxazolidin-2-imine was found to weakly inhibit iNOS. Further modifications of this compound resulted in a remarkable increase in both the in vivo and in vitro inhibitory activity and selectivity for iNOS.
Keywords
Inducible nitric oxide synthase inhibitor , 1 , 3-Oxazolidin-2-imine , selectivity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793975
Link To Document