Title of article
Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. Part 4: Heterocycles at C3
Author/Authors
Eddy W. Yue، نويسنده , , Susan V. DiMeo، نويسنده , , C. Anne Higley، نويسنده , , Jay A. Markwalder، نويسنده , , Catherine R. Burton، نويسنده , , Pamela A. Benfield، نويسنده , , Robert H. Grafstrom، نويسنده , , Sarah Cox، نويسنده , , Jodi K. Muckelbauer، نويسنده , , Angela M. Smallwood، نويسنده , , Haiying Chen، نويسنده , , Chong-Hwan Chang، نويسنده , , George L. Trainor، نويسنده , , Steven P. Seitz، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
343
To page
346
Abstract
New indeno[1,2-c]pyrazol-4-one cyclin dependent kinase inhibitors have been disclosed. The most promising compounds are nanomolar enzyme inhibitors with excellent activity against tumor cells. The most advanced compound retains cell culture activity even in the presence of human serum proteins. The most advanced compound did not kill the normal fibroblast line AG1523.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793982
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