Title of article
Synthesis and biological evaluation of nonpeptide integrin antagonists containing spirocyclic scaffolds
Author/Authors
Joanne M. Smallheer، نويسنده , , Carolyn A. Weigelt، نويسنده , , Francis J. Woerner، نويسنده , , Jennifer S. Wells، نويسنده , , Wayne F. Daneker، نويسنده , , Shaker A. Mousa، نويسنده , , Ruth R. Wexler، نويسنده , , Prabhakar K. Jadhav، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
5
From page
383
To page
387
Abstract
Analogues of isoxazoline αvβ3 antagonist 1 designed to further restrict the four carbon alkyl tether were prepared by incorporating two spirocyclic scaffolds, 1-oxa-2-azaspiro[4,5]dec-2-ene and 1-oxa-2,7-diazaspiro[4,4]non-2-ene. Additional optimization provided potent antagonists of both αvβ3 and α5β1 which are selective over GPIIb/IIIa.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793991
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