Title of article :
Enzymatic and hyperglycemia stability of chemically modified insulins with hydrophobic acyl groups
Author/Authors :
Kentaro Nakashima، نويسنده , , Makoto Miyagi، نويسنده , , Koichi Goto، نويسنده , , Yoko Matsumoto، نويسنده , , Ryuichi Ueoka، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Pages :
3
From page :
481
To page :
483
Abstract :
The acylated insulins were synthesized by the reaction of insulin protected by p-methoxybenzoxy carbonyl azide at Gly-A1 site with N-hydroxysuccinimide ester of caproic acid or benzoic acid (Cap-insulin and Bz-insulin). The noteworthy aspects are as follows: (a) the acylated insulins were more stable to the decomposition by various digestive enzymes as compared with native insulin in vitro. (b) Animal experiments using normal rats in vivo revealed that the Bz-insulin had an effective hypoglycemia activity almost similar to that of native insulin.
Keywords :
Acylated insulin , Diabetes , Digestive enzyme , hypoglycemia.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
2004
Journal title :
Bioorganic & Medicinal Chemistry Letters
Record number :
794013
Link To Document :
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