Title of article :
TMC-95A, a reversible proteasome inhibitor, induces neurite outgrowth in PC12 cells
Author/Authors :
Masayuki Inoue، نويسنده , , Haifeng Zhai، نويسنده , , Hayato Sakazaki، نويسنده , , Hidetomo Furuyama، نويسنده , , Yoshiyasu Fukuyama، نويسنده , , Masahiro Hirama، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
TMC-95A has been characterized as a potent proteasome inhibitor that binds to enzymes non-covalently at low nanomolar concentrations. Herein, the neuritogenic activity of TMC-95A in PC12 rat pheochromocytoma cells is reported for the first time. TMC-95A induced a positive neurite initiation of PC12 cells at concentration ranging from 1 to 20 μM.
Keywords :
Neuritogenesis , TMC-95A , PC12 cells , Peptides , proteasome inhibitor
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
