Title of article
Synthesis and evaluation of novel bacterial rRNA-binding benzimidazoles by mass spectrometry
Author/Authors
Yun He، نويسنده , , Jun Yang، نويسنده , , Baogen Wu، نويسنده , , Dale Robinson، نويسنده , , Kelly Sprankle، نويسنده , , Pei-Pei Kung، نويسنده , , Kristin Lowery، نويسنده , , V. Mohan، نويسنده , , Steve Hofstadler، نويسنده , , Eric E. Swayze، نويسنده , , Rich Griffey، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
5
From page
695
To page
699
Abstract
A series of novel benzimidazoles were efficiently synthesized using both solution- and solid-phase chemistry. These compounds were found to bind to the bacterial 16S ribosomal RNA A-site with micromolar affinities using unique mass spectrometry-based assays.
Keywords
San Diego , USA. , rRNA , Benzimidazoles , Mass spectrometry.* Corresponding author at present address.Departme nt of MedicinalChemistry , Genomics Institute of the Novartis Research Foundation(GNF) , 10675 John Jay Hopkins Drive , CA 92121
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794057
Link To Document