Title of article
Design of small molecule ketoamide-based inhibitors of cathepsin K
Author/Authors
John G. Catalano، نويسنده , , David N. Deaton، نويسنده , , Stacey T. Long، نويسنده , , Robert B. McFadyen، نويسنده , , Larry R. Miller، نويسنده , , J.Alan Payne، نويسنده , , Kevin J. Wells-Knecht، نويسنده , , Lois L. Wright، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
719
To page
722
Abstract
A novel series of ketoamide-based inhibitors of cathepsin K has been identified. Modifications to P2 and P3 elements were crucial to enhancing inhibitory activity. Although not optimized, a selected inhibitor was effective in attenuating type I collagen hydrolysis in a surrogate assay of bone resorption.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794061
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