Author/Authors :
YongQi Mu، نويسنده , , Matthew Nodwell، نويسنده , , John L. Pace، نويسنده , , Jeng-Pyng Shaw، نويسنده , , J. Kevin Judice، نويسنده ,
Abstract :
A series of lipidated vancomycin analogues 1 bearing disulfide bonds within their lipid chains was designed and synthesized to optimize their ADME profiles while retaining antibacterial potency. These compounds exhibited good activity against resistant organisms and low accumulation in tissues such as kidney and liver.
