Title of article
Novel nevirapine-like inhibitors with improved activity against NNRTI-resistant HIV: 8-heteroarylthiomethyldipyridodiazepinone derivatives
Author/Authors
C. Yoakim، نويسنده , , P.R. Bonneau، نويسنده , , R. Déziel، نويسنده , , L. Doyon، نويسنده , , J. Duan، نويسنده , , I. Guse، نويسنده , , Christine S. Landry، نويسنده , , E. Malenfant، نويسنده , , J. Naud، نويسنده , , W.W. Ogilvie، نويسنده , , J.A. OʹMeara، نويسنده , , D. R. Plante and G. von Oppen ، نويسنده , , B. Simoneau، نويسنده , , B. Thavonekham، نويسنده , , M. B?s، نويسنده , , M.G. Cordingley، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
739
To page
742
Abstract
A series of 8-heteroarylthiomethyldipyridodiazepinone derivatives were prepared and evaluated for their antiviral profile against wild type virus and the important K103N/Y181C mutant as an indicator for broad activity. 2,6-Dimethylpyridine derivative 16 was found to have a good pharmacokinetic profile in spite of poor metabolic stability in rat liver microsomes.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794065
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