Title of article
Synthesis of N,N′-disubstituted 3-aminobenzo[c] and [d]azepin-2-ones as potent and specific farnesyl transferase inhibitors
Author/Authors
Thierry Le Diguarher، نويسنده , , Jean Claude Ortuno، نويسنده , , David Shanks، نويسنده , , Nicolas Guilbaud، نويسنده , , Alain Pierré، نويسنده , , Eric Raimbaud، نويسنده , , Jean-Luc Fauchère، نويسنده , , John A Hickman، نويسنده , , Gordon C. Tucker، نويسنده , , Patrick J. Casara، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
5
From page
767
To page
771
Abstract
A structure–activity study was performed by synthesis on N,N′-disubstitution of 3-aminobenzo[c] and [d]azepin-2-one 2 and 3 to afford potent and specific farnesyl transferase inhibitors with low nM enzymatic and cellular activities.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794071
Link To Document