Title of article
N-4-Substituted-benzyl-N′-tert-butylbenzyl thioureas as vanilloid receptor ligands: investigation on the role of methanesulfonamido group in antagonistic activity
Author/Authors
Hyeung-geun Park، نويسنده , , Ji-yeon Choi، نويسنده , , Sea-hoon Choi، نويسنده , , Mi-kyung Park، نويسنده , , Jihye Lee، نويسنده , , Young-Ger Suh، نويسنده , , Hawon Cho، نويسنده , , Uhtaek Oh، نويسنده , , Jiyoun Lee، نويسنده , , Sang Uk Kang، نويسنده , , Jeewoo Lee، نويسنده , , Hee-Doo Kim، نويسنده , , Young-Ho Park، نويسنده , , Yeon Su Jeong، نويسنده , , Jin Kyu Choi، نويسنده , , Sang-sup Jew، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
5
From page
787
To page
791
Abstract
A series of N-4-substituted-benzyl-N′-tert-butylbenzyl thioureas were prepared for the study of their agonistic/antagonistic activities to the vanilloid receptor in rat DRG neurons. Their structure–activity relationship reveals that not only the two oxygens and amide hydrogen of sulfonamido group, but also the optimal size of methyl in methanesulfonamido group play an integral role for the antagonistic activity on vanilloid receptor.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794075
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