Author/Authors :
Roger Léger، نويسنده , , Corinne Benquet، نويسنده , , Xicai Huang، نويسنده , , Omar Quraishi، نويسنده , , Pieter van Wyk، نويسنده , , Dominique Bridon، نويسنده ,
Abstract :
Three peptide fragments of the kringle 5 region of plasminogen and their respective N- and C-terminus maleimido derivatives conjugated to Cys34 of human serum albumin were evaluated in vitro using a human umbilical vein endothelial cell (HUVEC) migration assay and a human plasma stability assay. The N-terminus maleimido derivative of the 64 to 74 segment of kringle 5 conjugated to human serum albumin possessed remarkable anti-migratory activity.
