Title of article :
A highly toxic morphine-3-glucuronide derivative
Author/Authors :
Mariona Salvatella، نويسنده , , Gemma Arsequell، نويسنده , , Gregorio Valencia، نويسنده , , Raquel E Rodr??guez، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
By the coupling of octylamine to the uronic acid function of morphine-3-glucuronide (M3G) a new glycoconjugate (morphine-3-octylglucuronamide, M3GOAM) was prepared. When assayed in both rats and mice up to ng/kg (ip) doses none of the animals survived. The aliphatic octyl chain may be the lethal factor since a closely related derivative (M3GNH2), was not toxic and showed similar opioid antagonist properties than naloxone.
Keywords :
Morphine glucuronides , Opioid antagonists , Alkylglycosides. , M3G
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
