Title of article
Novel inhibitors of fatty acid oxidation as potential metabolic modulators
Author/Authors
Elfatih Elzein، نويسنده , , Kevin Shenk، نويسنده , , Prabha Ibrahim، نويسنده , , Tim Marquart، نويسنده , , Suresh Kerwar، نويسنده , , Stephanie Meyer، نويسنده , , Hiba Ahmed، نويسنده , , Dewan Zeng، نويسنده , , Nancy Chu، نويسنده , , Daniel Soohoo، نويسنده , , Shirley Wong، نويسنده , , Kwan-Leung Chan MD FRCPC، نويسنده , , Jeff Zablocki، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
5
From page
973
To page
977
Abstract
We describe the synthesis of novel inhibitors of fatty acid oxidation as potential metabolic modulators for the treatment of stable angina. Replacement of the 2H-benzo[d]1,3-dioxolene ring system in our initial lead 3 with different benzthiazoles, benzoxazoles and introducing small alkyl substituents into the piperazine ring resulted in analogues with enhanced inhibitory activity against 1-14[C]-palmitoyl-CoA oxidation in isolated rat heart mitochondria (6, IC50=70 nM; 25, IC50=23 nM).
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794112
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