Author/Authors :
Jiabing Wang، نويسنده , , Michael J. Breslin، نويسنده , , Paul J. Coleman، نويسنده , , Mark E. Duggan، نويسنده , , Cecilia A. Hunt، نويسنده , , John H. Hutchinson، نويسنده , , Chih-Tai Leu، نويسنده , , Sevgi B. Rodan، نويسنده , , Gideon A. Rodan، نويسنده , , Le T. Duong، نويسنده , , George D. Hartman، نويسنده ,
Abstract :
A series of 3-substituted tetrahydro-[1,8]naphthyridine containing αvβ3 antagonists was prepared. A comparison of their in vitro IC50 values to the electron properties of the 3-substituents revealed a good linear Hammett correlation (ρ=−1.96, R2=0.959). Electron-withdrawing groups at the 3-position of the tetrahydro-[1,8]naphthyridine decreased potency while electron-donating groups enhanced potency.
