Author/Authors :
Xiangshu Fei، نويسنده , , Qi-Huang Zheng، نويسنده , , Ji-Quan Wang، نويسنده , , K. Lee Stone، نويسنده , , Tanya D. Martinez، نويسنده , , Kathy D. Miller، نويسنده , , George W. Sledge Jr، نويسنده , , Gary D. Hutchins، نويسنده ,
Abstract :
Radiolabeled antimitotic agents [11C]T138067 and [18F]T138067 have been synthesized for evaluation as new potential positron emission tomography (PET) biomarkers for cancer imaging. In vivo biodistribution and micro-PET imaging of [11C]T138067 were performed in breast cancer animal models MCF-7 transfected with IL-1α implanted athymic mice and MDA-MB-435 implanted athymic mice. The results suggest that the uptakes of [11C]T138067 in both MCF-7 transfected with IL-1α tumor and MDA-MB-435 tumor are non-specific binding.
