Author/Authors :
Roland W. Bürli، نويسنده , , Dustin McMinn، نويسنده , , Jacob A. Kaizerman، نويسنده , , Wenhao Hu، نويسنده , , Yigong Ge، نويسنده , , Quinn Pack، نويسنده , , Vernon Jiang، نويسنده , , Matthew Gross، نويسنده , , Martin Garcia، نويسنده , , Richard Tanaka، نويسنده , , Heinz E. Moser، نويسنده ,
Abstract :
Novel DNA minor-groove binding ligands with a promising antibacterial profile are described. Apart from excellent in vitro potency against multiple Gram-positive bacterial strains such as methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus faecalis (VRE), and penicillin-intermediate Streptococcus pneumoniae (PISP), a small subset of compounds was active against Gram-negative bacteria such as Escherichia coli (E. coli).
Keywords :
DNA binders , Minor groove , Lead optimization. , antibiotics
